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Metformin can rarely cause a serious condition called lactic acidosis. Metformin comes as a tablet and an extended-release tablet to take by mouth. Metformin is used when diet and exercise to prevent diabetes in people who are overweight. If the patient is taking Glucophage tablets, the starting dose is 500 mg daily with the evening meal or as directed by your doctor. Metformin helps to control the amount of sugar that your liver makes and that your stomach absorbs. Metformin belongs to the class of drugs known as biguanides. Overall, Metformin reduces blood sugar levels can rise too high.