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Depression it could be implicated in Celexa insomnia. Celexa appears to be safe to use on a long-term basis and may cause less withdrawal when use is stopped. Celexa is the newest antidepressant to be approved by theFDA. Like any antidepressant, not everyone responds or tolerates any given medication. Celexa is an antidepressant medication that affects neurotransmitters, the chemical transmitters within the brain. Do not take Celexa together with a monoamine oxidase inhibitor. Celexa may cause suicidal thoughts or ideation.