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Corticosteroids by the body. Prednisolone is a corticosteroid used to treat various inflammatory and allergy conditions as well as other diseases. Steroid medication needs may change if you have a fungal infection anywhere in your body. Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases. Prednisolone works by acting within cells to prevent the release of substances in the body that cause inflammation. Corticosteroids reduce the normal response of the immune system plays an important role. Corticosteroid. Deltasone is used in so many conditions, only the most common or established uses are mentioned here.