Esomeprazole reduce the production of acid in the stomach and intestines by blocking the enzyme in the wall of the stomach that produces acid. Nexium decreases the amount of acid backing up into the esophagus and causing reflux symptoms. You may require a dosage adjustment or special monitoring. The lowest available online and updated monthly. For injection. What should you watch for while taking Esomeprazole? Nexium is the newer formulation of the original Omeprazole product - both prescription drugs used to treat the infection, which is responsible for the majority of gastric ulcers. Esomeprazole works best if taken on an empty stomach at least one hour before meals and at the same time every day. Nexium is the newer formulation of the original Omeprazole product - both prescription drugs used to treat the symptoms of GERD and other conditions involving excessive stomach.