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Fluconazole is used for the treatment of serious fungal infections, especially of the central nervous system. Fluconazole works best when the amount of medicine in your body is kept at a constant level. In common with all azole antifungal agents, Fluconazole may cause hepatotoxicity. Diflucan comes as a tablet and liquid to take by mouth. Fluconazole can pass into breast milk and may harm a nursing baby. In common with all azole antifungal agents, Fluconazole may cause hepatotoxicity. Diflucan comes as a tablet and liquid to take by mouth usually taken once a day.